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Rapid Changes in Key Alzheimer's Protein Described in Humans
For the first time, researchers have described hour-by-hour changes in the amount of amyloid beta, a protein that is believed to play a key role in Alzheimer's disease, in the human brain.

SCIENCE

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October 20, 2008
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Stem Cell Transplantation Benefits Mice With Childhood Motor Neuron Disease
Researchers at the University of Milan, Italy, have generated data using a mouse model of Spinal Muscular Atrophy (SMA) to suggest that spinal cord neural stem cells (NSCs) might be a possible treatment for individuals with SMA.

Human Embryonic Stem Cells Implanted in Mice With MS, Slowed Down the Disease
Transplantation of human embryonic stem cells into the brains of a mouse with multiple sclerosis (MS) significantly slowed down the clinical symptoms and pathological manifestations of the disease, Hadassah physicians and scientists reported last week.

Receptor Activation Protects Retina From Diabetes Destruction
A drug known for it pain-relieving power and believed to stimulate memory appears to prevent diabetes induced retinal damage that leads to vision loss, researchers say.


ABSTRACTS

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Electrospun Poly(-caprolactone)/Gelatin Nanofibrous Scaffolds for Nerve Tissue Engineering
In this study, researchers constructed sevearal biocomposite scaffolds using varying ratios of PCL and gelatin concentrations and evaluated the chemical and mechanical properties of the constructed nerve fibers to determine which scaffolds produced the most effective viable tissues.

Neural Stem Cell Transplantation Can Ameliorate the Phenotype of a Mouse Model of Spinal Muscular Atrophy
Researchers at the University of Milan have generated data using a mouse model of spinal muscular atrophy to suggest that spinal cord neural stem cells might be a possible treatment for individuals with spinal muscular atrophy.

Essential Role of Structural Integrity and Firm Attachment of Surface-anchored Epidermal Growth Factor in Adherent Culture of Neural Stem Cells
Researchers had previously demonstrated that human epidermal growth factor, carrying a hexahistidine sequence at the C-terminus (hEGF-His), could be anchored to the Ni-chelated surface by coordination, providing a versatile subscrate for the selective proliferation of neural stem cells. In this study, the same group aims to gain deeper insight in to the basis of this hEGF-His, surface interaciton and obtain insights that are crucial for establishing the adherent culture and selective expansion of neural stem cells.

Topography of EEG Multivariate Phase Synchronization in Early Alzheimer's Disease
In this study, researchers analyze the surface topography of the multivariate phase synchronization (MPS) of multichannel EEG in 17 patients to examine whether Alzheimers disease is likely to disrupt the synchronization of the boielectrical processes in the distributed cortical networks underlying cognition.

Co-occurrence of Alzheimer's Disease ??-amyloid and Tau Pathologies at Synapses
In this study, researchers discover how pathological A?? and tau aggregation relate to each other and to alterations in neural synapses in Alzheimer's disease patients.


INDUSTRY

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STEMCELL Technologies Launches Direct Distribution to Germany & Austria
STEMCELL Technologies Inc. a leader in specialty cell culture media, cell separation products and ancillary reagents for life science research, announced the opening of a new sales office on September 1, 2008 in Köln, Germany, providing direct service to Germany and Austria.

Banyan Biomarkers Announces U.S. Patent for Neural Proteins as Biomarkers for Traumatic Brain Injury
Banyan Biomarkers, Inc. announced today that the U.S. Patent and Trademark Office has granted U.S. Patent No. 7,396,654 B2 "Neural Proteins as Biomarkers for Traumatic Brain Injury," licensed exclusively by Banyan Biomarkers from the University of Florida.

Stem Cell Therapeutics Corp. Receives Positive Review from Data Safety & Monitoring Board
The REGENESIS Phase IIb clinical trial designed to demonstrate that the NTxTM-265 therapy is both a safe and effective therapy capable of improving recovery after acute ischemic stroke, has completed a safety analysis and has recommended the trial continue as per the protocol.

Biotech Group Not Endorsing for Prez, But Seeks More in FDA Budget
The world's largest biotechnology organization isn't endorsing a candidate for president yet when the next U.S. leader is elected, the Biotechnology Industry Organization's members will call on him to significantly increase the federal Food and Drug Administration's budget.

Neurologix Licenses Exclusive Rights to Key Gene from Aegera Therapeutics for Use as a Potential Gene Therapy for Huntington's Disease
Pursuant to the agreement, Neurologix has exclusively licensed the worldwide rights, excluding China, for the use of the XIAP gene (x-linked inhibitor of apoptosis protein) for therapeutic or prophylactic purposes in the treatment of Huntington's disease.

Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) Grants
The National Institutes of Health has awarded $42.2 million to fund 38 exceptionally innovative research projects that could have an extraordinarily significant impact on many areas of science.


POLICY

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Updated Guidelines for Stem Cell Research Released
The National Academies today released amended guidelines for research involving human embryonic stem cells, revising those that were issued in 2005 and updated in 2007.

FDA Seeks to Establish Branch Office in China
This October the FDA plans to open an office at the U.S. embassy in Beijing in an effort to implement a cost-effective, prevention-based approach to risk management.



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