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ABSTRACTS
A Zebrafish Model of Tauopathy Allows in Vivo Imaging of Neuronal Cell Death and Drug Evaluation
This study generated fluorescently labeled TAU transgenic zebrafish, which rapidly recapitulated key pathological features of tauopathies, including phosphorylation and conformational changes of human TAU protein, tangle formation, neuronal and behavioral disturbances, and cell death.
Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell Model
The researchers developed a technology that uses recombinant human mitochondrial transcription factor A (TFAM) engineered with an N-terminal protein transduction domain followed by SOD2 mitochondrial localization signal to deliver mtDNA cargo to mitochondria of living cells.
A Novel Three-Dimensional Culture System for Isolation and Clonal Propagation of Neural Stem Cells Using a Thermo-Reversible Gelation Polymer
In the present report, the researchers examined the possible utility of a three-dimensional culture system using a thermo-reversible gelation polymer to isolate and expand neural stem cells.
Linking Asymmetric Cell Division to the Terminal Differentiation Program of Postmitotic Neurons in C. elegans
This study establishes a transcriptional cascade linking asymmetric division to a large battery of terminal differentiation genes' differentiation program.
Development of Cloned Embryos from Porcine Neural Stem Cells and Amniotic Fluid-derived Stem Cells Transfected with Enhanced Green Fluorescence Protein Gene
This study assessed the developmental ability of embryos cloned from porcine neural stem cells, amniotic fluid-derived stem cells, fetal fibroblast cells, adult fibroblast, and mammary gland epithelial cells.
Efficient Production of Mesencephalic Dopamine Neurons by Lmx1a Expression in Embryonic Stem Cells
This study shows that forced expression of Lmx1a, a transcription factor functioning as a determinant of mesDA neurons during embryogenesis, effectively can promote the generation of mesDA neurons from mouse and human ESCs.
p66ShcA Adaptor Molecule Accelerates ES Cell Neural Induction
This reports establishes that p66ShcA is up-regulated during in vitro neural induction in embryonic stem cells.
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