Neural Cell News 3.42, October 21, 2009. Click here if you are unable to see images in this e-mail.


TOP STORIES

Neural Stem Cells Show Promise for Treating Age-Related Macular Degeneration
StemCells, Inc. announced recently new preclinical data showing that its human neural stem cells protect cone photoreceptors in the eye from progressive degeneration and preserve visual function long term. [StemCells, Inc., Palo Alto]

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SCIENCE NEWS

Webinar: Standardized Media and Reagents for Neural Stem Cell Research 

California Stem Cell, Inc. and Families of Spinal Muscular Atrophy Announce Completion of Pre-IND Meeting with FDA for Stem Cell-derived Therapy for the 
Treatment of Spinal Muscular Atrophy Type I California Stem Cell, Inc. and Families of Spinal Muscular Atrophy announced recently that they have completed a formal pre-Investigational New Drug meeting to initiate human trials for a stem cell-derived motor neuron replacement therapy for Spinal Muscular Atrophy Type I. [California Stem Cell, Inc., Irvine]

Presentation of Adult Stem Cell Study Highlights Promising Application of Autologous Stem Cells for Treatment of Spinal Cord Injury
DaVinci Biosciences LLC announced recently the presentation of their safety and feasibility study demonstrating the administration of autologous bone marrow derived stem cells for the treatment of acute and chronic spinal cord injury. [DaVinci Biosciences LLC, Costa Mesa]

Gene Therapy for Parkinson's "Encouraging" in Early Trials
A gene therapy for Parkinson's disease that has been tested on lab monkeys is showing good early results in a small-scale trial on humans. [Henri Mondor Hospital, Paris]

Dysfunctional Protein Dynamics Behind Neurological Disease?
Researchers have taken a snapshot of proteins changing shape, sticking together and creating structures that are believed to trigger deadly processes in the nervous system. The discovery opens the possibility of designing drugs for a devastating neurological disease, ALS. [Lund University, Lund]

Wayne State Study Shows Adult Stem Cell Grafts Help Paralyzed
A recent study details the outcome of adult stem cell grafts in spinal cord injuries and how that procedure led to increased mobility and quality of life for the participating patients. [Wayne State University School of Medicine, Detroit]

Tissue Engineering Could Improve Hand Use for Wounded Soldiers
The researchers created what they called an "artificial neuromuscular junction", the body's own nerve-muscle connections, composed of muscle cells and a nano-sized polymer placed on a biological scaffold. [University of Michigan, Ann Arbor]

Researchers Reveal Mechanism for Neuron Self-preservation
A study finds that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement. [Stanford University School of Medicine, Stanford]

'Spaghetti' Scaffolding Could Help Grow Skin in Labs
Researchers at the University of Bristol have taken a novel biologically-inspired track for the production of synthetic biocompatible hydrogels, which could  be used to grow new tissues tailored to the needs of individual patients. [University of Bristol, Bristol]

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Animal Protein-Free
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by STEMCELL Technologies
 
 
WATCH THE TeSR2 VIDEO STEMCELL Technologies Inc
 




CURRENT PUBLICATIONS

Dopamine Gene Therapy for Parkinson's Disease in a Nonhuman Primate Without Associated Dyskinesia
To investigate gene therapy for Parkinson's disease, the researchers simulated the disease in macaque monkeys by treating them with the complex I mitochondrial inhibitor 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which induces selective degeneration of dopamine-producing neurons. [Science]

Immune Influence on Adult Neural Stem Cell Regulation and Function
Known and speculative roles that immune signaling plays in the postnatal and adult brain, focusing on how environments encountered in disease or injury may influence the activity and fate of endogenous or transplanted NSCs are reviewed. [Neuron]

MHC Class I: An Unexpected Role in Neuronal Plasticity
Lasting structural change at synapses is clearly evident during critical periods of activity-dependent neural development, and accumulating evidence has established a surprising role for the major histocompatibility complex class I proteins in this process. [Neuron]

CD38/cADPR/Ca2+ Pathway Promotes Cell Proliferation and Delays Nerve Growth Factor-induced Differentiation in PC12 Cells
Here the role of one endogenous Ca2+-mobilizing nucleotide, cyclic adenosine diphosphoribose (cADPR), in the proliferation and differentiation of neurosecretory PC12 cells was explored. [JBC]

Harnessing Immune Alterations in Neurodegenerative Diseases
Immune dysfunction's emerging role as an early and active participant in neuropathology is presented here. [Neuron]

How Good Are Neuron Models?
Opinions strongly diverge on what constitutes a good model of a neuron. [Science]

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INDUSTRY NEWS

Biotechs Back From The Dead
The financial crisis was supposed to annihilate small companies, but many survived.




POLICY NEWS

California and China Agree to Collaborate on Stem Cells
The California Institute for Regenerative Medicine and the Chinese Ministry of Science and Technology have agreed to collaborate on stem cell research.

Court Asked to Overturn Obama's Decision to Fund Embryonic Stem Cell Research
A hearing was held Wednesday to reinstate a ban on taxpayer funds being used for embryonic stem cell research.




EVENTS

Restoration of Neural Tissue and Function Workshop
Novemer 4, 2009
Washington DC, United States

The Biology and Pathology of Tau and its Role in Tauopathies
7-8 January, 2010
Cambridge, United Kingdom

Alzheimer's Disease Beyond Abeta
January 10-15, 2010
Copper Mountain, United States

Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

Keystone Symposium B4 Stem Cell Differentiation and Dedifferentiation
February 15 - 20, 2010
Keystone, United States

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States



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