TOP STORIES

Regeneration Can be Achieved after Chronic Spinal Cord Injury
Scientists report that regeneration of central nervous system axons can be achieved in rats even when treatment delayed is more than a year after the original spinal cord injury. [University of California, San Diego School of Medicine, San Diego]

SCIENCE NEWS

Researchers Find Brain Cell Transplants Help Repair Neural Damage
A Swiss research team has found that using an animal's own brain cells (autologous transplant) to replace degenerated neurons in select brain areas of donor primates with simulated but asymptomatic Parkinson's disease and previously in a motor cortex lesion model, provides a degree of brain protection and may be useful in repairing brain lesions and restoring function. [University of South Florida, Tampa]

Caltech Researchers Show Efficacy of Gene Therapy in Mouse Models of Huntington's Disease
Researchers have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models. [California Institute of Technology, Pasadena]

Modifying Neural Stem Cells Improves Their Therapeutic Efficacy
Researchers have genetically engineered adult neural stem cells to express the anti-inflammatory molecule IL-10 and found that these cells induced more extensive functional and pathological recovery from ongoing disease than did non-engineered aNSCs. [Thomas Jefferson University, Philadelphia]

CURRENT PUBLICATIONS

Combined Intrinsic and Extrinsic Neuronal Mechanisms Facilitate Bridging Axonal Regeneration One Year after Spinal Cord Injury
In this study, the researchers report that combinatorial therapies administered 6 weeks, and as long as 15 months, after SCI promote axonal regeneration into and beyond a midcervical lesion site. [Neuron]

The Neural Stem Cell Line CTX0E03 Promotes Behavioral Recovery and Endogenous Neurogenesis After Experimental Stroke in a Dose-Dependent Fashion
This study investigated behavioral recovery in rats following implanting increasing doses of CTX0E03 cells into the putamen ipsilateral to the stroke damage. [Neurorehabil Neural Repair]

Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal
Using mouse strains found to span the range of responsiveness to chronic hypoxia, this study correlated differential neural stem cell survival and self-renewal with differences in behavior. [Am J Pathol]

Diffusion Tensor Imaging to Assess Axonal Regeneration in Peripheral Nerves
In this study, the researchers examined the use of ex vivo high-resolution DTI for imaging intact and regenerating peripheral nerves in mice and correlated the MRI findings with electrophysiology and histology. [Exp Neurol]

INDUSTRY NEWS

Geron and FDA Reach Agreement on Clinical Hold
In discussions with the company, the FDA has advised that it concurs with Geron that positive data from this study and Geron expects the data from this study to enable re-initiation of the clinical trial in the third quarter of 2010.

POLICY NEWS

CIRM, the UK and Canada Award more than $250 Million to Accelerate the Pace of Bringing Stem Cell Therapies to the Clinic
The California Institute for Regenerative Medicine, the state stem cell agency, and two international partners awarded more than $250 million to 14 multidisciplinary teams of researchers in California, the UK and Canada to develop stem cell-based therapies for 11 diseases.

Ontario Targets $25 Million for Stem Cell Research
The Ontario government will announce $25 million for stem cell research as part of an initiative to encourage collaboration among scientists across the province and around the world.

EVENTS

Restoration of Neural Tissue and Function Workshop
November 4, 2009
Washington DC, United States

The Biology and Pathology of Tau and its Role in Tauopathies
January 7-8, 2010
Cambridge, United Kingdom

Alzheimer's Disease Beyond Abeta
January 10-15, 2010
Copper Mountain, United States

Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

Keystone Symposium B4 Stem Cell Differentiation and Dedifferentiation
February 15-20, 2010
Keystone, United States

2010 Canadian Neuroscience Meeting
May 15-18, 2010
Ottawa, Canada

ISSCR 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

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