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CURRENT PUBLICATIONS
Transplantation of Embryonic Neural Stem/Precursor Cells Overexpressing BM88/Cend1 Enhances the Generation of Neuronal Cells in the Injured Mouse Cortex
In this study, neural stem/precursor cells derived from embryonic day 14.5 mouse cortex were genetically modified via transduction with a lentiviral vector to over express the neuronal lineage-specific regulator BM88/Cend1 that co-ordinates cell cycle exit and differentiation of neuronal precursors. [Stem Cells]
Rescue of Radiation-induced Cognitive Impairment through Cranial Transplantation of Human Embryonic Stem Cells
To explore the possibility of ameliorating radiation-induced cognitive impairment, athymic nude rats subjected to head only irradiation (10 Gy) were transplanted 2 days afterward with human embryonic stem cells into the hippocampal formation and analyzed for stem cell survival, differentiation, and cognitive function. [PNAS]
Effects of Granulocyte Colony-stimulating Factor on the Proliferation and Cell-fate Specification of Neural Stem Cells
The researchers here show that granulocyte-colony stimulating factor could stimulate the proliferation of neural stem cells and promote their differentiation in vitro. [Neuroscience]
Human Cord Blood-Derived Hematopoietic and Neural-Like Stem/Progenitor Cells Are Attracted by the Neurotransmitter GABA
Since human umbilical cord blood contains stem/progenitor cells able to generate either neuronal or hematopoietic cells, the researchers evaluated the effect of GABA on this type of cells. [Stem Cells Dev]
Sprouty2 Down-regulation Promotes Axon Growth by Adult Sensory Neurons
This study investigated the expression of Sprouty isoforms in adult sensory neurons of dorsal root ganglia as well as the effects of Sprouty inhibition on axon growth by small interfering RNAs. [Mol Cell Neurosci]
Fasudil, a Rho Kinase Inhibitor, Drives Mobilization of Adult Neural Stem Cells after Hypoxia/Reoxygenation Injury in Mice
Here, the researchers used the model of hypoxia/reoxygenation injury to explore the possibility whether Fasudil, a ROCK inhibitor in clinical application for subarachnoid hemorrhage and stroke, mobilizes adult neural stem cells in vivo. [Mol Cell Neurosci]
Schwann Cells Engineered to Express the Cell Adhesion Molecule L1 Accelerate Myelination and Motor Recovery After Spinal Cord Injury
In this study, the researchers used retroviral transduction to genetically modify Schwann cells from transgenic GFP-mice in order to over express the cell adhesion molecule L1, a protein promoting neurite outgrowth and implicated in myelination. [Exp Neurol]
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