LABORATORY RESEARCH

Inherited Genetic Variant Predisposes to Aggressive but Not Indolent Prostate Cancer
This study demonstrates that inherited variants predisposing to aggressive but not indolent prostate cancer exist in the genome, and suggests that the clinical potential of such variants as potential early markers for risk of aggressive prostate cancer should be evaluated. [Proc Nat Acad Sci]

Role of Cationic Channel TRPV2 in Promoting Prostate Cancer Migration and Progression to Androgen Resistance
Findings establish a role for transient receptor potential vanilloid 2 (TRPV2) in prostate cancer progression to the aggressive castration-resistant stage, prompting evaluation of TRPV2 as a potential prognostic marker and therapeutic target in the setting of advanced prostate cancer. [Cancer Res]

Analysis of the Molecular Networks in Androgen Dependent and Independent Prostate Cancer Revealed Fragile and Robust Subsystems
Researchers constructed and analyzed a mathematical model of the integration between hormone growth factor signaling, androgen receptor activation, and the expression of cyclin D and prostate-specific antigen in human LNCaP prostate adenocarcinoma cells. [PLoS ONE]

Molecular Characterisation of ERG, ETV1 and PTEN Gene Loci Identifies Patients at Low and High Risk of Death from Prostate Cancer
The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status. [Brit J Cancer]

Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) Gene: Cell-Specific Expression and Transcriptional Regulation by Androgen in Transgenic Mouse Testis
The regulatory region(s) in the gonadotropin-regulated testicular RNA helicase (GRTH ) gene that is/are required for its cell-specific expression in the testis and human chorionic gonadotropin/androgen dependent expression were investigated in transgenic mice carrying sequential deletions of 5' flanking sequences of the GRTH gene. [J Cell Biochem]

Androgen Receptor Sequence and Variations in Several Common Prostate Cancer Cell Lines
Researchers used direct nucleotide sequencing to genotype the entire exogenous coding region of the androgen receptor in ten commonly used prostate cancer cell lines. [Cancer Biol Ther]

Hedgehog Signaling Regulates Proliferation of Prostate Cancer Cells Via Stathmin1
Hedgehog signaling regulates proliferation of prostate cancer cells by controlling stathmin1 expression. [Clin Exp Med]

CLINICAL RESEARCH

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
PROSTVAC-VF treatment was evaluated for safety and for prolongation of progression-free survival and overall survival in a randomized, controlled, and blinded phase II study. [J Clin Oncol]

Prostate Cancer Treatment for Economically Disadvantaged Men
The authors compared the types of treatments prostate cancer patients received from county hospitals and private providers as part of a statewide public assistance program. [Cancer]

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CHI's Molecular Medicine Tri-Conference 2010
February 3-5, 2010
San Francisco, United States

AACR/JCA Joint Conference: Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
February 5-9, 2010
Waikoloa, United States

SMi's Second Annual Stem Cells 2010
February 15-16, 2010
London, United Kingdom

Keystone Symposia: Stem Cell Differentiation and Dedifferentiation (B4)
February 15-20, 2010
Keystone, United States

5th Annual Stem Cell Summit
February 16, 2010
New York, United States

Third International Symposium on Focal Therapy and Imaging of Prostate and Kidney Cancer
February 24-27, 2010
Washington, DC, United States

2010 Genitourinary Cancers Symposium: Progress in Multidisciplinary Management
March 5-7, 2010
San Francisco, United States

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

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Research & Development Scientist - Pancreatic Cell Biology (STEMCELL Technologies)

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Research & Development Scientist - Epithelial Cell Biology (STEMCELL Technologies)

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