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Prostate Cell News 1.16, May 7, 2010.
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SCIENCE NEWS
Zoledronic Acid Prevents Fractures in Prostate Cancer With Bone Metastases
Monthly infusions of the bisphosphonate zoledronic acid significantly reduce the risk for bone fractures in men with prostate cancer and malignant bone metastases. [Press release from Medscape discussing research presented at the European Association of Urology 25th Annual Congress]
Prostate Cancer Test a Flop in Study
A technique that urologists had hoped would make it possible to distinguish men with prostate cancer who need treatment from those who would only need watchful waiting didn't work well, researchers report. [Press release from Medline Plus discussing online prepublication in Journal of Clinical Oncology]
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CURRENT PUBLICATIONS
LABORATORY RESEARCH
8q24 Prostate, Breast, and Colon Cancer Risk Loci Show Tissue-Specific Long-Range Interaction with MYC
In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. [Proc Natl Acad Sci U S A]
Molecular Origin of Plasma Membrane Citrate Transporter in Human Prostate Epithelial Cells
The prostate is a highly specialized mammalian organ that produces and releases large amounts of citrate. However, the citrate release mechanism is not known. Here, researchers present the results of molecular cloning of a citrate transporter from human normal prostate epithelial PNT2-C2 cells shown previously to express such a mechanism. [EMBO Rep]
ENMD-1198, A New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties
In this in vitro study, researchers investigated the antivascular properties of ENMD-1198, a new anticancer drug currently in clinical trials. [Mol Cancer Ther]
Role of the Protein Tyrosine Phosphatase SHP-1 in Interleukin-6 Regulation of Prostate Cancer Cells
SHP-1 suppresses growth and increases apoptosis in both LNCaP and LNCaP-IL6+ cells, which suggests that SHP-1 could be a therapeutic target in prostate cancer, even when there is an IL-6-related growth advantage. [Prostate]
Armoring CRAds with p21/Waf-1 shRNAs: The Next Generation of Oncolytic Adenoviruses
In this study, researchers investigated the importance of the cyclin-dependent kinase inhibitor p21/Waf-1, on viral replication and tumor growth. [Cancer Gene Ther]
Targeting MMP-9, uPAR, and Cathepsin B Inhibits Invasion, Migration and Activates Apoptosis in Prostate Cancer Cells
In this study, the therapeutic potential of siRNA-mediated targeting of matrix metalloproteinase-9 (MMP-9), urokinase plasminogen activator receptor (uPAR), and cathepsin B in prostate cancer was carried out using single and bi-cistronic siRNA-expressing constructs. [Cancer Gene Ther]
Xeno-Oestrogens and Phyto-Oestrogens are Alternative Ligands for the Androgen Receptor
This study aimed to use a computerized docking approach to examine the interactions between the human androgen receptor and phyto-oestrogens (genistein, daidzein, and flavone) and xeno-oestrogens [bisphenol A, 4-nonylphenol, dichlorodiphenyl trichloroethane (DDT), diethylstilbestrol (DES)]. [Asian J Androl]
NBRI16716A, A New Antitumor Compound Against Human Prostate Cancer Cells, Produced by Perisporiopsis Melioloides Mer-f16716
Researchers isolated three new natural compounds, NBRI16716A (1), NBRI16716B (2) and NBRI16716C (3), from the fermentation broth of Perisporiopsis melioloides Mer-f16716, although compound 2 was already reported as a chemical degradation product of isotriornicin. [J Antibiot]
CLINICAL RESEARCH
Prostate-Specific Antigen Kinetics During Follow-Up Are an Unreliable Trigger for Intervention in a Prostate Cancer Surveillance Program
The purpose of this study was to assess the predictive ability of prostate-specific antigen velocity and doubling time for biopsy progression and adverse pathology at prostatectomy among men with low-risk prostate cancer enrolled on an active-surveillance program. [J Clin Oncol]
Expression Signature of E2F1 and Its Associated Genes Predict Superficial to Invasive Progression of Bladder Tumors
In approximately 20% of patients with superficial bladder tumors, the tumors progress to invasive tumors after treatment. Current methods of predicting the clinical behavior of these tumors prospectively are unreliable. Researchers aim to identify a molecular signature that can reliably identify patients with high-risk superficial tumors that are likely to progress to invasive tumors. [J Clin Oncol]
A Prospective, Multicenter, National Cancer Institute Early Detection Research Network Study of [-2]proPSA: Improving Prostate Cancer Detection and Correlating with Cancer Aggressiveness
The study objective was to characterize the clinical utility of serum prostate-specific antigen (PSA) isoform, [-2]proPSA, for prostate cancer detection and assess its association with aggressive disease. [Cancer Epidemiol Biomarkers Prev]
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INDUSTRY NEWS
Details of New Wellcome Trust Investigator Awards Announced
The Wellcome Trust announces further details of its Investigator Awards, a major new scheme to support world-class researchers to tackle ambitious research questions about health and disease. [Wellcome Trust Press Release]
Synta Pharmaceuticals Reports First Quarter 2010 Financial Results
Synta Pharmaceuticals Corp., a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, reported financial results for the quarter ended March 31, 2010. [Synta Pharmaceuticals Corp. Press Release]
BioSante Pharmaceuticals Announces Reinitiation of Prostate Cancer Vaccine Development
BioSante Pharmaceuticals, Inc. announced that development of its GVAX Prostate Cancer Vaccine (GVAX Prostate) for the treatment of prostate cancer has been reinitiated. [BioSante Pharmaceuticals, Inc. Press Release]
Mistakes, Little Oversight Cited for Philadelphia VA Prostate Cancer Treatment
When doctors from the University of Pennsylvania performed prostate cancer procedures at the Philadelphia VA Medical Center, they made dozens of mistakes over six years, and investigators could find no evidence that anyone was providing oversight, concluded a report issued by the Department of Veterans Affairs Inspector General's Office. [The Philadelphia Inquirer]
U.S. Reviews Diabetes, Heart Risk with Prostate Drugs
The U.S. Food and Drug Administration is examining if certain hormone treatments for men with prostate cancer pose a greater risk of diabetes or heart problems than other therapies. [Reuters]
Insiders at Dendreon Cash In on Drug Approval
Dendreon Corp. President and Chief Executive Mitchell Gold sold more than $28 million of company stock in the hours after the U.S. Food and Drug Administration approved the cancer treatment Provenge late last week. [The Wall Street Journal]
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POLICY NEWS
Science Panel Cuts Authorization Levels for Three COMPETES Agencies
The House of Representatives Science and Technology Committee today scaled back proposed funding levels for three key science agencies as part of its reauthorization of the America COMPETES Act. [The House of Representatives Science and Technology Committee, United States]
Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants
The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commision, European Union]
Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092) [National Institutes of Health, United States]
Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 { NOT-AR-10-035) [National Institutes of Health, United States]
Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States]
Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States]
Guidance for Industry: Requalification Method for Reentry of Blood Donors Deferred Because of Reactive Test Results for Antibody to Hepatitis B Core Antigen (Anti-HBc); Availability (Docket No. FDA-2008-D-0263) [Food and Drug Administration, United States]
Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety and Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]
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EVENTS
American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
35th European Society for Medical Oncology (ESMO) Congress
October 8–12, 2010
Milan, Italy
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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