SCIENCE NEWS
Cancer: Trapping the Escape Artist
Researchers outline how the six anti-apoptotic proteins in the Bcl-2 family are expressed differently in different cancers. [Press release from the Sanford-Burnham Medical Research Institute discussing online prepublication in Cell Death and Disease]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Synthesis and Antitumor Properties of Selenocoxib-1 Against Rat Prostate Adenocarcinoma Cells
Researchers used a novel strategy to combine properties of two well-studied class of compounds (selenium and COX-2 inhibitor) and examined the resulting effectiveness against prostate cancer. [Int J Cancer]
ERG Rearrangement is Specific to Prostate Cancer and Does Not Occur in any Other Common Tumor
Aim of this study was to assess, whether the ERG rearrangement and the distinct deletion site between TMPRSS2 and ERG, both predominantly resulting in a TMPRSS2–ERG fusion, occur in tumors other than prostate cancer. [Modern Pathol]
Thrombospondin-1 Regulates the Normal Prostate In Vivo Through Angiogenesis and TGF-Beta Activation
Researchers evaluated angiogenic activity in human prostate epithelial and stromal cells treated with androgens and hypoxia in vitro. [Lab Invest]
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model
Mice deficient in IDO expression were crossed to TRAMP mice and the time to the appearance of palpable tumors were measured. [Prostate]
Prostate Cancer in African-American Men and Polymorphism in the Calcium-Sensing Receptor
Researchers genotyped three CaSR single nucleotide polymorphisms for 458 African American prostate cancer cases and 248 controls from a population-based case-control study, the California Collaborative Prostate Cancer Study. [Cancer Biol Ther]
Cyclic Bisbibenzyls Induce Growth Arrest and Apoptosis of Human Prostate Cancer PC3 Cells
The results suggest that cyclic bisbibenzyls could be used for the development of novel therapeutic chemicals against prostate cancer. [Acta Pharmacologica Sinica]
A Survey of the Anti-Apoptotic Bcl-2 Subfamily Expression in Cancer Types Provides a Platform to Predict the Efficacy of Bcl-2 Antagonists in Cancer Therapy
Researchers investigated the mRNA expression levels of all six antiapoptotic Bcl-2 subfamily members in 68 human cancer cell lines using quantitative PCR techniques and measured the ability of known Bcl-2 inhibitors to induce cell death in 36 of the studied tumor cell lines. [Cell Death & Disease]
CLINICAL RESEARCH
The Effect of Study Arm on Prostate Cancer Treatment in the Large Screening Trial ERSPC
Prostate cancer (PC) mortality is the most valid end-point in screening trials, but could be influenced by the choice of initial treatment if treatment has an effect on mortality. In this study, PC was compared between the screening and control arms in a screening trial. [Int J Cancer]
Effect of Aspirin, Other NSAIDs, and Statins on PSA and PSA Velocity
Data from 140 men with prostate cancer enrolled in a Phase II clinical trial of selenium to prevent prostate cancer progression were analyzed to determine association between aspirin, other NSAIDs, or statin use with baseline serum prostate-specific antigen (PSA) levels and PSA velocity (rate of PSA change over time) using repeated measures over an average follow-up time of 3.2 years. [Prostate]
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EVENTS
American Urological Association (AUA) 2010 Annual Meeting
May 29-June 3, 2010
San Francisco, United States
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
35th European Society for Medical Oncology (ESMO) Congress
October 8–12, 2010
Milan, Italy
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