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Prostate Cell News 1.23, June 25, 2010.
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Estimation of Effect Size Distribution from Genome-Wide Association Studies and Implications for Future Discoveries
Researchers report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies. [Nat Genet]
Integrative Genomic Profiling of Human Prostate Cancer
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in ~11% of tumors. [Cancer Cell]
Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis
Here, researchers have undertaken a genetic analysis in the mouse to determine the role of Brca2 in the adult prostate. [PLoS Genet]
Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells
Here, researchers report that Etk is upregulated in both human and mouse prostates in response to androgen ablation. [Cancer Res]
Differential Roles of ERK and Akt Pathways in Regulation of EGFR-Mediated Signaling and Motility in Prostate Cancer Cells
In this study, researchers use the human prostate cancer cell lines, DU145 and PC3, to investigate the effects of both the ERK and Akt pathways on epidermal growth factor (EGF)-mediated EGFR signaling, trafficking and cell motility. [Oncogene]
The Wnt Inhibitory Factor 1 Restoration in Prostate Cancer Cells was Associated with Reduced Tumor Growth, Decreased Capacity of Cell Migration and Invasion and a Reversal of Epithelial to Mesenchymal Transition
Researchers investigated the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, WIF1, on the growth and cellular invasiveness of a bone metastatic prostate cancer cell line, PC3. [Mol Cancer]
Robust Multi-Tissue Gene Panel for Cancer Detection
Researchers have identified a set of genes whose relative mRNA expression levels in various solid tumors can be used to robustly distinguish cancer from matching normal tissue. [BMC Cancer]
Alterations in LMTK2, MSMB and HNF1B Gene Expression are Associated with the Development of Prostate Cancer
Researchers measured the expression and isoform usage of seven prostate cancer candidate genes in benign and malignant prostate by real-time PCR, and correlated these factors with cancer status and genotype at the genome wide association studies risk variants. [BMC Cancer]
CLINICAL RESEARCH
Chlordecone Exposure and Risk of Prostate Cancer
Researchers analyzed the relationship between exposure to chlordecone and the risk of prostate cancer. [J Clin Oncol]
Outcomes in Localized Prostate Cancer: National Prostate Cancer Register of Sweden Follow-Up Study
A 10-year prostate cancer-specific mortality of 2.4% among patients with low-risk prostate cancer in the surveillance group indicates that surveillance may be a suitable treatment option for many patients with low-risk disease. [J Natl Cancer Inst]
Maximum Tumor Diameter: A Simple Independent Predictor for Biochemical Recurrence after Radical Prostatectomy
The significance of maximum tumor diameter in biochemical recurrence (BCR) prediction was evaluated using radical prostatectomy specimens of 364 patients with a BCR of 18% (n=66) during a mean follow-up of 37.4 months. [Prostate Cancer Prostatic Dis]
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POLICY NEWS
Hospital Clínic de Barcelona Obtained the First Accreditation for Cell Therapy Research
The certification, awarded for the first time in Catalonia, allows the Hospital Clínic de Barcelona to produce drugs in gene therapy, cell therapy and tissue engineering. [Spanish Medicines Agency, Spain]
New Videos Reveal How NIH Identifies the Most Promising Research Applications
The National Institutes of Health's Center for Scientific Review released a new video to show new applicants and others how NIH assesses over 80,000 grant applications each year to help find those with the most merit. [National Institutes of Health, United States]
NIH and Wellcome Trust Announce Partnership to Support Genomic, Population-Based Studies in Africa
The National Institutes of Health (NIH) and the Wellcome Trust announced a partnership with African researchers to conduct genetic and environmental studies in Africa of common, non-communicable disorders, such as heart disease and cancer, as well as communicable diseases, such as malaria. [National Institutes of Health, United States]
Publication of New Enforcement Strategy
A new enforcement strategy has been published by the Inspection, Enforcement and Standards Division. [Medicines and Healthcare Products Regulatory Agency, United Kingdom]
FDA/CDRH Public Meeting: Oversight of Laboratory Developed Tests (LDTs), Date July 19-20, 2010 [Food and Drug Administration, United States]
Drugs Designated as Orphan Drugs [Therapeutic Goods Administration, Australia]
Therapeutic Goods Committee (TGC) (Updated) [Therapeutic Goods Administration, Australia]
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EVENTS
21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway
Translational Cancer Medicine 2010 - USA
July 11-14, 2010
San Francisco, United States
United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom
2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore
CHI's 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy
35th European Society for Medical Oncology (ESMO) Congress
October 8–12, 2010
Milan, Italy
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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