TOP STORY

How Prostate Cancer Packs a Punch 
Researchers uncovered a mechanism that determines prostate cancer aggressiveness, providing new targets for diagnosis and treatment. [Press release from Sanford Burnham Medical Research Institute discussing the online publication in Cancer Cell]

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SCIENCE NEWS

How Does Broccoli Stop Prostate Cancer?
Researchers have found that sulforaphane, a chemical found in broccoli, interacts with cells lacking a gene called PTEN to reduce the chances of prostate cancer developing. [Press release from the Institute of Food Research discussing online publication in Molecular Cancer]

Enhancer of Prostate Cancer Risk Located in Gene Desert
A genetic variant implicated in several cancers by genome-wide association studies has been found to drive increased expression of a known oncogene in the prostate. [Press release from EurekAlert! discussing online prepublication in Genome Research]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
Tissue-specific expression of FoxA2 combined with Siah2-dependent HIF-1(alpha) availability enables a transcriptional program required for neuroendocrine (NE) prostate tumor development and NE phenotype in prostate adenocarcinomas. [Cancer Cell]

An 8q24 Gene Desert Variant Associated with Prostate Cancer Risk Confers Differential In Vivo Activity to MYC Enhancer
In this study, researchers used an in vivo bacterial artificial chromosome enhancer-trapping strategy in mice to scan a half-megabase of the 8q24 gene desert encompassing the prostate cancer-associated regions for long-range cis-regulatory elements. [Genome Res]

A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing
Researchers used endogenous zinc as an imaging biomarker for prostate cancer detection and progression monitoring. [Cancer Res]

Gamma-Tocotrienol as an Effective Agent in Targeting Prostate Cancer Stem Cell-Like Population
Here, researchers demonstrated for the first time that gamma-tocotrienols can down-regulate the expression of prostate cancer stem cell markers (CD133/CD44) in androgen independent prostate cancer cell lines (PC-3 and DU145). [Int J Cancer]

Association of Core Binding Factor(Beta) With the Malignant Phenotype of Prostate and Ovarian Cancer Cells
To test whether Core Binding Factor (CFB) is required for the malignant phenotype of various epithelial cancers, researchers used lentiviral delivery of CBF(beta)-specific shRNA to significantly decrease CBF(beta) expression in two prostate cancer cell lines (PPC1 and PC-3) and the SKOV-3 ovarian cancer cell line. [J Cell Physiol]

Posttranslational Regulation of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) in Mouse PTEN Null Prostate Cancer Cells: Enhanced Surface Expression and Differential O-Glycosylation of MT1-MMP
The study’s data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated PI3K/AKT activation and posttranslational regulation of MT1-MMP, which may play a role in PC progression. [Biochim Biophys Acta]

The Dietary Isothiocyanate Sulforaphane Modulates Gene Expression and Alternative Gene Splicing in a PTEN Null Preclinical Murine Model of Prostate Cancer
In this study, researchers investigate the interaction between sulforaphane, a dietary isothiocyanate derived from broccoli, PTEN expression and gene expression in pre malignant prostate tissue. [Mol Cancer]

CLINICAL RESEARCH

Serum Follistatin in Patients with Prostate Cancer Metastatic to the Bone
The clinical significance of circulating follistatin (FLST) was investigated in patients with prostate cancer.  [Clin Exp Metastas]

Prostate Cancer: Recent Trends in Korea
Researchers investigated the yearly changes in the baseline prostate-specific antigen levels and the incidence of prostate cancer in men screened at their health promotion center from 1995 to 2008 to determine the trends in prostate cancer in Korea. [Urol Int]

INDUSTRY NEWS

Eden Biodesign Assists Momotaro-Gene; Inc. to Commence Human Clinical Trials Less Than 12 Months After Being Engaged to Produce a Recombinant Adenovirus Vector From a New Cell Line
Eden Biodesign Ltd. and Momotaro-Gene, Inc. announced the success of a collaborative global project that demonstrated Eden's capabilities to work quickly to develop an adenoviral manufacturing process providing Momotaro-Gene with drug substance and vialed drug product ready for their clinical trial within 12 months. [Eden Biodesign Ltd. Press Release]

Genesis Genomics Renamed Mitomics; Company Announces Key Executive Appointments and Additions to Board of Directors
Mitomics announced that its shareholders have voted to change the company name from Genesis Genomics Inc. to Mitomics Inc., effective immediately. [Mitomics Inc. Press Release]

Theragenics announces Supply and Reseller Agreement with Oncura
Theragenics Corporation announced that it has signed an agreement with Oncura, Inc. for the distribution of TheraSeed® palladium-103 brachytherapy seeds. [Theragenics Corporation Press Release]

Calypso Medical to Showcase Radiation Safety Benefits of the Calypso® System at AAPM Annual Meeting
Calypso Medical Technologies Inc. announced it will demonstrate radiation safeguard features of the Calypso System at the 52nd Annual Meeting of the American Association of Physicists in Medicine (AAPM). [Calypso Medical Technologies Inc. Press Release]

POLICY NEWS

Britain Delays Controversial Assessment Scheme for Research
Britain's new science minister made good a manifesto pledge when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom]

Spanish Science Spending Lockdown
Spain's science and innovation minister said that research funding will be "frozen or minimally reduced" as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain] 

Maryland Stem Cell Research Commission Elects Margaret Conn Himelfarb as Chair
The Maryland Stem Cell Research Commission announced that it has elected Margaret Conn Himelfarb as chair and Bowen P. Weisheit, Jr. as vice chair. [Maryland Stem Cell Research Commission, United States]

Harold Varmus Sworn in as National Cancer Institute’s 14th Director
Nobel Prize winner Harold E. Varmus, M.D., took the oath of office to become the National Cancer Institute’s 14th director. [National Cancer Institute, United States]

Notice of Intent to Publish Funding Opportunity Announcement (FOA) for Support of Cancer Epidemiology Cohorts  [National Cancer Institute, United States]

Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States]

EVENTS

35th European Society for Medical Oncology (ESMO) Congress
October 8–12, 2010
Milan, Italy

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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