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Prostate Cell News 1.27, July 23, 2010.
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SCIENCE NEWS
BMD Testing Underused in ADT Recipients
Bone mineral density (BMD) testing and bisphosphonate use are significantly underused in men receiving androgen deprivation therapy (ADT) for prostate cancer, a new study suggests. [Renal & Urology News on study presented at the Canadian Urological Association’s Annual Meeting]
Salvage Cryotherapy an Option for Radiation Treatment Failures
New findings from a Canadian study support the use of salvage cryotherapy for prostate cancer patients who experience disease recurrence after radiation treatment. [Renal & Urology News on study presented at the Canadian Urological Association’s Annual Meeting]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH
Castration Resistance in Human Prostate Cancer is Conferred by a Frequently Occurring Androgen Receptor Splice Variant
Here, investigators have identified a novel human androgen receptor splice variant in which exons 5, 6, and 7 are deleted and demonstrated that this variant can contribute to cancer progression in human prostate cancer xenograft models in mice following castration. [J Clin Invest]
3[Beta]-Hydroxysteroid Dehydrogenase Is a Possible Pharmacological Target in the Treatment of Castration-Resistant Prostate Cancer
The findings demonstrate that dehydroepiandrosterone and [delta]5-androstenediolmust be metabolized by 3[beta]-hydroxysteroid dehydrogenase to activate androgen receptor in these models of castration-resistant prostate cancer. [Endocrinology]
Proteomic Profiling of Potential Molecular Targets of Methyl-Selenium Compounds in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model
The present work applied iTRAQ proteomic approach to profile protein changes of the TRAMP prostate and characterized their modulation by methylselenic acid and Se-methylselenocysteine to identify their potential molecular targets. [Cancer Prev Res]
Genome-Wide Analysis of Androgen Receptor Binding and Gene Regulation in Two CWR22-Derived Prostate Cancer Cell Lines
In this study, researchers investigated androgen receptor (AR) binding and AR-dependent transcription in two related castrate-resistant cell lines derived from androgen-dependent CWR22 relapsed tumors: CWR22Rv1 and CWR-R1. [Endocr Relat Cancer]
P53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase
Based on the results, PIM1 will have its most profound effects on tumorigenesis in situations where the senescence response is inactivated. [Mol Canc Res]
Cryptotanshinone Sensitizes DU145 Prostate Cancer Cells to Fas(APO1/CD95)-Mediated Apoptosis Through Bcl-2 and MAPK Regulation
In the present study, researchers demonstrated that the apoptosis inhibitory protein, Bcl-2, was highly expressed in response to Fas in DU145 prostate cancer cells, thereby conferring resistance to apoptosis. [Cancer Lett]
Knockdown of Akt isoforms by RNA Silencing Suppresses the Growth of Human Prostate Cancer Cells In Vitro and In Vivo
Here, researchers investigated the expression and function of Akt isoforms in human prostatic carcinoma cells. [Biochem Biophys Res Commun]
CLINICAL RESEARCH
Diagnosis of Prostate Cancer by Detection of Minichromosome Maintenance 5 Protein in Urine Sediments
In this study, researchers investigated minichromosome maintenance-5 as a urinary biomarker for prostate cancer detection. [Br J Cancer]
Open-Label, Phase I Dose-Escalation Study of Sodium Selenate, a Novel Activator of PP2A, in Patients with Castration-Resistant Prostate Cancer
Sodium selenate is well tolerated at a dose of 60mg per day with modest single-agent efficacy similar to other anti-angiogenic agents. [Br J Cancer]
Prostate Specific Antigen Velocity Does Not Aid Prostate Cancer Detection in Men With Prior Negative Biopsy
Researchers determined whether prostate specific antigen velocity could predict repeat biopsy results in men with persistently increased prostate specific antigen after initial negative biopsy. [J Urol]
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POLICY NEWS
USC to Lead Prostate Cancer Study
Researchers received a $12 million National Cancer Institute grant to lead an international project aimed at identifying new biological pathways critical to the development and potential treatment of prostate cancer. [USC Norris Comprehensive Cancer Center ]
"Game Over" for British Science?
The Royal Society and the British Academy strongly warned the British government that looming cuts to science funding could be "irreversibly catastrophic for the future of U.K. science and economic growth" if they go too far. [The Royal Society and the British Academy, United Kingdom]
House Panel Approves 3.2% Raise for NIH in 2011
A House of Representatives spending panel yesterday approved a $1 billion increase, to $32 billion, in the 2011 budget for the National Institutes of Health (NIH). [National Institutes of Health, United States]
2011 NIH Directors New Innovator Award Program (DP2) (RFA-RM-10-009) [National Institutes of Health, United States]
Prospective Grant of Exclusive License: The Development of Human Therapeutics for the Treatment of Cancer [National Institutes of Health, United States]
Pre-Application Meeting for Request for Applications (RFA-CA-10-016) for the Clinical Proteomic Technologies for Cancer Initiative (CPTC): Proteome Characterization Centers (NOT-CA-10-031) [National Institutes of Health, United States]
Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States]
NIMH Announces Availability of Funds for Competitive Revision Applications for a Repository Supporting Stem Cell Research Relevant to Mental Disorders (U24) (NOT-MH-10-024) [National Institute of Mental Health, United States]
NASA SBIR/STTR 2010 Phase I Solicitation [Small Business Innovation Research, United States]
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EVENTS (Listed by Date)
The Tissue and Cell Engineering Society 2010 Meeting
July 28-30, 2010
Manchester, United Kingdom
2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore
9th Mount Desert Island Stem Cell Symposium
August 6-7, 2010
Salsbury Cove, United States
NEW Australian-Canadian Prostate Cancer Research Alliance Symposium
August 6-8, 2010
Gold Coast, Australia
CHI's 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States
2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China
Joint Annual Meeting of the International Continence Society (ICS) and International Urogynecological Association (IUGA)
August 23-27, 2010
Toronto, Canada
Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland
Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland
28th World Congress of Endourology and SWL
September 1-4, 2010
Chicago, United States
NEW Prostate Cancer Research Institute Conference 2010
September 11-12, 2010
California, United States
International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy
Tissue Engineering and Regenerative Medicine International Society (TERMIS) - Asia Pacific 2010
September 15-17, 2010
Sydney, Australia
35th European Society for Medical Oncology (ESMO) Congress
October 8–12, 2010
Milan, Italy
NEW Frontiers in Tumour Progression
October 24-27, 2010
Madrid, Spain
NEW Cancer Pharmacogenetics: Personalising Medicine
November 22-24, 2010
Madrid, Spain
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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