[Human Skeletal Muscle Aging Atlas] Researchers profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment.

[Cytoskeleton] The authors investigated the impact of endothelial cell-specific partial loss of profilin1 expression in atherosclerosis development.

[FEBS Letters] The authors investigated the function of DMT1 isoform lacking the iron-response element in normal and malignant hematopoiesis.

[Stem Cell Research & Therapy] In vitro culture of isolated CD34+, common myeloid progenitors, and CD34+ CD371– hematopoietic stem progenitor cells were performed to assay the differentiation potential of monocytes, neutrophils, and erythrocytes.

[Antioxidants & Redox Signaling] Scientists studied the effect and mechanism of hypoxia on erythroid differentiation of K562 cells and observed the effect of hypoxia on early erythropoiesis of zebrafish.

[Blood] Researchers showed that GM-CSF programmmed myeloid committed progenitors to produce trained macrophages but programmed the upstream non-committed LKS+ progenitors to produce tolerized macrophages.

[Blood Advances] In this randomized controlled feasibility trial conducted in seven hospitals in Australia and New Zealand, scientists enrolled patients with secondary hypogammaglobulinemia with either a history of recurrent/severe infection or an immunoglobulin G level <4 g/L.

[Clinical Cancer Research] Investigators performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML.

[Cellular & Molecular Biology Letters] The authors review the eminent role of reactive oxygen species in the hematological niche and their profound influence on the progress of myelodysplastic syndromes.

[Innate Pharma] Innate Pharma SA announced that the first patient was dosed in the Phase II dose expansion part of the Sanofi-sponsored clinical trial of SAR443579 / IPH6101, evaluating SAR443579 as a monotherapy for the treatment of blood cancers with high unmet needs.

[BBC] The University of Sheffield was given more than £2.5m funding to look into dormant cancer cells and develop new treatments for myeloma, a type of blood cancer.

[Cell Death Discovery] GSE14359 chip from the GEO database was used to screen differentially expressed genes in osteosarcoma (OS). DNA polymerase epsilon 2 (POLE2) was confirmed to overexpress in OS tissues and cell lines by immunohistochemical staining, qPCR, and Western blot.