Keep Current with the Latest in Cell Biology Research

Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection

[Cell] Investigators compared exopolysaccharide-producers versus non-producers and a virulent Escherichia coli lung infection model in male and female mice.

KN046, a Bispecific Antibody against PD-L1 and CTLA-4, Plus Chemotherapy as First-Line Treatment for Metastatic NSCLC: A Multicenter Phase II Trial

[Cell Reports Medicine] In this multicenter phase II trial, patients with nonsquamous (non-sq) NSCLC receive pemetrexed, whereas those with sq-NSCLC receive paclitaxel, plus KN046 and carboplatin. Following four cycles, maintenance therapy included KN046 with pemetrexed for non-sq-NSCLC and KN046 for sq-NSCLC.

Activation of Polyamine Catabolism Promotes Glutamine Metabolism and Creates a Targetable Vulnerability in Lung Cancer

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists reported that activation of polyamine catabolism promoted glutamine metabolism, leading to a targetable vulnerability in lung cancer.

Enigmatic Exosomal Connection in Lung Cancer Drug Resistance

[Molecular Therapy - Nucleic Acids] Investigators summarize the current knowledge on conventional and emerging drug resistance mechanisms and the involvement of exosomes as well as exosome-mediated factors mediating drug resistance in lung cancer.

Abnormal Expression of Krüppel-Like Transcription Factors and Their Potential Values in Lung Cancer

[Heliyon] The authors review the recent some progresses of the oncogenic Krüppel-like factors with their potential values for diagnosis, prognosis and molecular target in lung cancer.

£1.7 Million for the World’s First Vaccine to Prevent Lung Cancer

[Cancer Research UK] Researchers at the University of Oxford, the Francis Crick Institute and University College London have been granted £1.7 million of funding from Cancer Research UK and the CRIS Cancer Foundation to develop a lung cancer vaccine.

Metformin Boosts Anti-tumor Immunity and Improves Prognosis in Upfront Resected Pancreatic Cancer: An Observational Study

[JNCI-Journal Of The National Cancer Institute] Researchers investigated the influence of metformin on patient survival and its potential correlation with distinct immune profiles in PDAC tumors.

Unveiling the Role of PYGB in Pancreatic Cancer: A Novel Diagnostic Biomarker and Gene Therapy Target

[Journal Of Cancer Research And Clinical Oncology] Scientists constructed a risk diagnostic model of pancreatic cancer (PC)-related genes by WGCNA and LASSO regression and found PYGB, an essential gene in PC. Then, we explored the pro-carcinogenic role of Brain glycogen phosphorylase in PC by in vivo and in vitro experiments.

Rintatolimod in Advanced Pancreatic Cancer Enhances Anti-Tumor Immunity through Dendritic Cell-Mediated T Cell Responses

[Clinical Cancer Research] Investigators studied the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of advanced PDAC patients.

The BulkECexplorer Compiles Endothelial Bulk Transcriptomes to Predict Functional versus Leaky Transcription

[Nature Cardiovascular Research] Researchers presented the BulkECexplorer compendium of 240 bulk RNA-seq datasets from five vascular endothelial cell subtypes. This resource reported transcript counts for genes of interest and predicts whether detected transcripts were likely the products of active or leaky gene expression.

Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment

[ACS Nano] Post ischemic stroke, hypoxia/hypoglycemia provoked the up-regulation of transmembrane glucose transporters and iron transporters due to multiple metabolic disorders, especially in brain endothelial cells. Scientists developed a myricetin oligomer-derived nanostructure doped with Ce to bypass the blood-brain barrier which was cointermediated by glucose transporters and iron transporters such as glucose transporters 1, sodium/glucose cotransporters 1, and transferrin reporter.

Sensitive Detection of Multiple Blood Biomarkers via Immunomagnetic Exosomal PCR for the Diagnosis of Alzheimer’s Disease

[Science Advances] An immunomagnetic exosomal polymerase chain reaction platform was developed using DNA-conjugated antibodies for the rapid detection of amyloid-β and phosphorylated tau in clinical blood exosomes.

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

spot_img