[American Journal of Physiology - Endocrinology and Metabolism] Human mesenteric vascular endothelial cells and human umbilical vein endothelial cells were treated with Testo with or without a NOX4 inhibitor or NOX4 siRNA.

[Disease Models & Mechanisms] Researchers investigated and characterized the effects of mechanical stimulation on the expression of angiogenic factors in retinal pigment epithelial cells both in vitro and in a mouse model.

[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.

[Immunity & Ageing] The authors discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.

[Clinical Infectious Diseases] COVID-OUT was a 2 × 3 randomized, placebo-controlled, double-blind trial that assessed metformin, fluvoxamine, and ivermectin; 999 participants self-collected anterior nasal swabs on day 1, day 5, and day 10.

[Journal Of Clinical Investigation] The authors summarize the status of therapeutic vaccines for herpes simplex virus, cytomegalovirus, and Epstein-Barr virus and proposes approaches for future development.

[Journal Of Gastroenterology] Researchers established patient-derived organoids for pancreatic ductal adenocarcinoma and evaluated their application in subtype classification and clinical outcome prediction.

[International Immunopharmacology] In vitro, a TNF-α-induced colonic organoid model was established to test the direct effect of sclareol on inflammation-induced intestinal barrier injury and inflammatory response. The Nrf2/NF-κB/MLCK signaling was analyzed to explore the mechanism of sclareo.

[Clinical Cancer Research] Transcriptomics and high dimensional flow cytometry revealed changes in murine tumor dendritic cells that not only mediated Treg infiltration after radiotherapy, but were associated with worse survival in human cancer datasets.

[Journal Of Nanobiotechnology] The release of α, β-Methyleneadenosine 5′-diphosphate suppressed the adenosine generation via CD73 blockade, alleviating the impairment of adenosine to dendritic cells and suppressing regulatory T cells, and synergically stimulated the activity of T cells.

[Journal For Immunotherapy Of Cancer] Investigators highlighted the interaction between bipositive TAMs or cancer cells and T cells was predominantly focused on FXYD6+ T cells rather than regulatory T cells, whereas, FXYD6+ T cells were further identified as a group of novel immunosuppressive T cells.

[Anova Enterprises, Inc.] Anova Enterprises, Inc. has collaborated with University of California at San Francisco, University of California at San Diego, University of Southern California, and Denovo Biopharma to manage a newly awarded $11.8M California Institute for Regenerative Medicine (CIRM) grant to support the development of DB107 in patients with newly diagnosed high-grade glioma.