Keep Current with the Latest in Cell Biology Research
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Design of a Stem Cell–Based Therapy for Ependymal Repair in Hydrocephalus Associated with Germinal Matrix Hemorrhages
[Stroke] Investigators explored the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors, and mesenchymal stem cells.
Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing
[Pigment Cell & Melanoma Research] Using a cell enrichment strategy to isolate KIT+/CD45− cells from the telogen skin of adult female C57BL/6J mice, investigators evaluated the transcriptional landscape of quiescent melanocyte stem cells at high resolution.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte- Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Oncogene-Induced Matrix Reorganization Controls CD8+ T Cell Function in the Soft-Tissue Sarcoma Microenvironment
[European Journal Of Clinical Investigation] Scientists investigated how ECM composition modulated CD8+ T cell function in undifferentiated pleomorphic sarcoma, an immunologically active desmoplastic tumor.
Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells
[Advanced Materials] Bottlebrush polymers were synthesized and crosslinked to form poly(ethylene glycol)-based hydrogels and used to study how strain-stiffening behavior affects human MSCs.
Bortezomib Suppresses Acute Myelogenous Leukemia Stem-Like KG-1a Cells via NF-κB Inhibition and the Induction of Oxidative Stress
[Journal Of Cellular And Molecular Medicine] Scientists investigated the anti-acute myelogenous leukemia (AML) activity of bortezomib, emphasizing its anti-leukemic stem cells potential, using KG-1a cells, an AML cell line with stem-like properties.
Integrated Drug Profiling and CRISPR Screening Identify BCR::ABL1-Independent Vulnerabilities in Chronic Myeloid Leukemia
[Cell Reports Medicine] The authors performed ex vivo drug screening of CML CD34+ leukemic stem/progenitor cells using 100 single drugs and tyrosine kinase inhibitor-drug combinations and identify sensitivities to Wee1, MDM2, and BCL2 inhibitors.
Dutch Cancer Society Grant to Study How Fatty Liver Disease Can Contribute to Liver Cancer
[Hubrecht Institute] Delilah Hendriks, researcher from the Organoid group, Oncode researcher, and affiliated group leader at the Princess Máxima Center has received a Young Investigator Grant from the Dutch Cancer Society.
Increased Uterine Arterial Tone, Stiffness and Remodeling with Augmented Matrix Metalloproteinase-1 and -7 in Uteroplacental Ischemia-Induced Hypertensive Pregnancy
[Biochemical Pharmacology] Scientists tested whether hypertensive pregnancy involved localized aberrations in uterine arterial tone, stiffness and remodeling by matrix metalloproteinases.
A Single Chain Variable Fragment Antibody (TN 64) Cognate to Fibronectin Type III Repeats Promotes Corneal Wound Healing by Inhibiting Fibrosis
[International Immunopharmacology] The authors showed that Tn64 bound to Tn fn repeats 3–5. Unlike other Tn fn domains, Tn fn 3–5 displayed no inhibition of fibronectin matrix assembly.
Resistance Training-Induced Changes in Muscle Proteolysis and Extracellular Matrix Remodeling Biomarkers in the Untrained and Trained States
[European Journal Of Applied Physiology] Scientists examined how proteolysis-related biomarkers and ECM remodeling factors respond to a bout of resistance training in the untrained and trained state.
Sophoridine Exerts Anti-Arthritic Effects on Fibroblast-Like Synoviocytes and Collagen-Induced Arthritis in Rats
[Phytotherapy Research] A collagen-induced arthritis rat model and tumor necrosis factor alpha-induced fibroblast-like synoviocytes were utilized to investigate the inhibitory effect of Sophoridine on hreumatoid arthritis.