[Nature Communications] The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.

[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.

[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.

[Nature Communications] Investigators designed membrane permeant peptide inhibitors that specifically target the primary interface between TANGO1 and cTAGE5, an interaction that is required for collagen export from endoplasmic reticulum exit sites

[Journal Of Agricultural And Food Chemistry] Research indicated that TFDG administration effectively lowered the fasting blood glucose and serum lipid concentrations and enhanced the functionality and cellular architecture of the liver and kidney in rats with diabetes.

[Journal Of Materials Chemistry B] The authors introduce the mechanisms and effects of native extracellular vesicles derived from different cells and tissues to treat liver diseases of different etiologies.

[PLOS One] The authors explored the association of stemness indicators with survival outcomes and clinical characteristics by combining clinical information and survival analyses.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that hepatocyte-restricted expression of a single chain c-Jun~Fra-2 protein, which functionally mimiced the c-Jun/Fra-2 AP-1 dimer, resulted in spontaneous HCC formation in c-Jun~Fra-2hep mice.

[Nature News] The US National Institutes of Health (NIH) said it will raise the salaries of thousands of postdoctoral researchers and graduate students who receive a prestigious NIH research fellowship. The move could boost pay for other scientists as well, because academic institutions often follow guidelines set by the NIH.

[STAT News] Scientists reported on Monday, April 22 that they used a form of the technology known as “base editing” to alter the DNA of laboratory monkeys in the womb, substantially reducing the levels of a toxic protein that causes a fatal liver disease before the animals had even been born.

[Journal Of Clinical Investigation] Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.

[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.